USA picked up six Gold Medals (sixteen total) on Day Seven of competition, and didn't gain any ground, at all, remaining firmly in fourth place in Gold Medals, and fifth overall.
- Sam Grewe wins the men's high jump (Category T63: Lower Body impairment). Sam had most of his right leg amputated below the knee, after developing osteosarcoma as a teenager.
- Breanna Clark wins the women's 400m (Category T20: Intellectual impairment), with a World Record 55.18s. Breanna was diagnosed with autism when she was four years old. Her mother won silver in the women's 4x400m relay at the Montreal Olympics. Breanna also won Gold at the Rio Paralympics.
- Shawn Morelli wins the women's road cycling time trial (Category 4: Lower Body impairment, or low-level neurological impairment). Shawn was blinded in her left eye, and sustained permanent spine and brain trauma, after being hit by an IED, while serving in Afghanistan. This is Shawn's second medal at the Tokyo Paralympics, and she also previously won two Gold Medals in Rio.
- Oksana Masters wins the women's road cycling time trial (Category H5: Lower Body impairment). Oksana was born in Khmelnytskyi, Ukraine, three years after the Chernobyl accident, and it is believed that the radioactive fallout from the accident played a role in Oksana being born with tibial hemimelia, as well as other birth defects. She has had both legs amputated above the knee. Oksana is a multiple-time Paralympic medalist, having previously won Gold at the Pyeongchang Paralympics, in 2018, and intends to defend her Gold Medals at the Beijing Paralympics, in 2022.
- Morgan Stickney wins the women's 400m freestyle (Category S8: Lower Body impairment). Morgan had her left leg amputated below the knee, after developing a staph infection at 21 years old. She then had her right leg amputated below the knee, at 22 years old, after being diagnosed with a rare vascular disorder.
- Mikaela Jenkins wins the women's 100m butterfly (Class S10: Lower Body impairment). Mikaela was born with proximal femoral focal deficiency, causing one leg to be significantly longer than the other. Her left foot was amputated, when she was eight months old.