this draft is so dependent on our ideas that some greats may not even get taken.
Still, I thought I'd be able to nab my leading man first and hold off on my leading lady. But Gadget and Slim spooked me and because this woman really is the only person I could legitmately see in this role, my first overall pick is:

Salma Hayek
Taking into account my genre and the fact that Hayek is my first pick, some of you may already know what I'm aiming at. But eh, I'll wait a few more rounds before I start talking about it openly.
I will say Hayek is, as I mentioned, the only person I could think of who could provide both star power/name recognition and depth/legitimacy to the very central figure in my film.
I can fill the leading man role with half a dozen solid actors, but in my mind, Hayek is the optimal choice for my lady.