I thought Matthew Perry was great in The Whole Nine Yards, thought he was okay in The Whole Ten Yards, and loved Fools Rush In for reasons that had nothing to do with him. I can't recall any other movie I've seen him in, off the top of my head. I've only seen around ten episodes of Friends from start to finish, and he was only part of the A-plot in two of them.
I'll probably remember him most for his struggles with substance abuse, and the work he did to help others deal with same. RIP.