I'm inclined to agree with sdballer here, at least as a general thought. Too late to change this league, and I don't really mess with settings much anyway, but with that many players taken it does seem like it would make the draft and injuries count for much more than anything else.
And of course the solution in my mind would be to reduce the rosters, not the number of teams.
I also considered making the playoffs 8 teams instead of 6. With 18 teams I think 8 would have been fine, and it only removes byes from the top two teams. But again, I just thought of it yesterday so I felt like that was too late to make a change. I don't like changing rules near or after the draft.