*Manu (along with every starter not named Duncan or Parker) has played limited minutes (around 25) this season, and with their new depth it doesn't look like that's going to change.
*Vince is a risk I would take (he played 77 games last year, and 73 before that) and is an overall upgrade over Hughes (except in steals).
I concur with OhBoy, if someone offers you vince for larry, take it like the gift it is...
Manu for Larry is another matter...right now their stats are almost the same, though Manu has more 3's and rebounds...I think that Hughes would get more PT than Ginobili and thus have the better chance to put up more stats. I'd roll the dice and keep Larry.