I think if you watch the pilot you won't be totally lost. It's hard to say, having come from watching BSG, but I get the impression it's going to stand on its own for the most part.
You're right in thinking that there are going to be references that will be meaningful as backstory - one of the main characters from BSG is a child in Caprica, several motifs from BSG are being explained, etc. But I don't think that's the focus of the show. BSG painted the 50 years or so leading up to its own opening in very broad historical brushstrokes. Caprica is going to fill in the details on how that history started/played out. I think it's got a chance to be interesting to non-BSG watchers because there's some good depth to the storyline.